Date: 2009may25 Keywords: Postfix Q. Postfix: Why is my Postfix mail server rejecting mail to a domain with the error "Relay access denied (in reply to RCPT TO command)" ? A. This probably means the the machine that's hosting example.com doesn't see example.com as local (ie needs to be relayed to). Add this to your /etc/postfix/main.cf file:

mydestination = ..., example.com